Luke Lee

Title

Quantum Nanoplasmonics and Cellular BASICs for Quantitative Biology and Medicine

Abstract

Cellular Biological Application Specific Integrated Circuits (BASICs) have been developed for quantitative systems biology and molecular medicine. A library of "building blocks" is under development to produce multifunctional biochip systems for future quantitative biology and systematic bioinformatics. Important modules of cellular BASICs include Integrated Multiple Patch-clamp Array Chip Technology (IMPACT), integrated dynamic cell culture vessels and multiplexed bioreactors, integrated devices for cell lysis, cell separation, single cell electroporation, dynamic single-cell analysis, and cell-to-cell communication. Another area of research includes Gold quantum nanoplasmonic particles, which are ideal probes for nanoscale spectroscopic mole cular imaging, photothermal therapeutic, and gene regulation applications. Nanophotonic crescents have structures with a sub-10 nm sharp edge, which can enhance local electromagnetic field at the edge area. Nanocrescent probes can be used for label-free molecular detection and promote the understanding of electron transfers in biomolecules, which has enormous benefits in early disease detection, drug discovery, and gene regulations.